This happens when you enable the HTTPS with your own certificates. In my case, I have configured Anypoint runtime fabrics with self-generated certification using the following command:
openssl req -x509 -newkey rsa:4096 -keyout key.pem -out cert.pem -days 365The above command generates two files: cert.pem and key.pem. The purpose of them is beyond the scope of the article. The error will occur when the local mule flow calls the remote application, which is deployed in the Anypoint Runtime Fabrics.