Most effective programming language ?

I'm using a fairly standard MSI mobo with Intel Core i5-6400 processor and 64 GB RAM.
So: Which programming language (besides assembly) is the most effective to use in this configuration when I want to do calculations/modelling trying to find the least number of combinations to fullfill some predefined conditions.

More specific I have i.e. 5 sets of combinations each containing three different states: A, B and C.
This gives me a total number of 243 combinations.
Theoretically it is possible to reduce this number of combinations to 23 so that no matter what combination of the original 243 you choose you'll always have 4 out of 5 of them correct.

If you have 4 sets of combinations the theoretically minimum of combinations fullfilling this requirement is 9 (and those 9 combinations are available today).

So I want to know what programming language should I use ?
(I'm able to put all the combinations in memory to speed up the process).

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