In case you're wondering, VB6 programs run on Windows 11. Programs with a manifest have the appropriate Windows 11 appearance. The IDE works as well, although it seems to aggravate the known Windows 11 Taskbar flickering issue, but it settles down quickly.
The only issue I have found so far is that command button mnemonics do not appear after pressing the Alt key is you use a manifest. This can be solved by 1) not using a manifest file, or 2) changing the Windows setting to always show mnemonics.
Please note, I started with Windows 10 and upgraded to Windows 11. I assume an original Windows 11 install would work the same.
Best wishes to all.