Clean all my settings VB.NET

Hi, how can I clean all saved settings in my.settings ? Do I need only to put
my.settings.[name].clear() or a My.settings.reset() can do a good job for all the user setting added into the program?
Also how can I add an exception if there is nothing in that setting or all settings? Can I put like
the isnullorempthy and referring it to that particular setting?

If ask = Msgboxresult.Yes then
my.settings.[name1].clear()
my.Settings.reset()
if ask = msgboxresult.no then
end if